5-Amino-1MQ is a small-molecule NNMT inhibitor rather than a true peptide, studied for its effects on NAD+ metabolism and fat storage. Research sits at the preclinical stage with cell and rodent data but no human trials, and it stays a research chemical with no FDA approval. Educational, not medical advice.
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) -- NOT a peptide. By inhibiting NNMT it is thought to preserve nicotinamide for the NAD+ salvage pathway and reduce adipocyte lipid storage, increasing intracellular NAD+ and energy expenditure.
Half-life
Not well established in humans; pharmacokinetic data are limited. It is a small molecule, not a peptide.
Regulatory status
Not FDA-approved. No known completed NNMT-targeting human clinical trials. Sold as a research chemical / for laboratory use only.
Safety
Human safety data are essentially absent; effects, side effects, and long-term risks are uncharacterized in people. Treat all human-use claims as unsupported.
Evidence
Preclinical only -- in vitro and rodent studies; no published human clinical trials.
Sources
Neelakantan H, et al. Selective membrane-permeable NNMT inhibitors reverse high-fat-diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. https://pubmed.ncbi.nlm.nih.gov/29155147/
Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. https://pubmed.ncbi.nlm.nih.gov/24717514/
Neelakantan H, Brightwell CR, Graber TG, et al. NNMT inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. https://pubmed.ncbi.nlm.nih.gov/30753815/
Dimet-Wiley A, Wu Q, Wiley JT, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022;12(1):484. https://pubmed.ncbi.nlm.nih.gov/35013352/
Awosemo O, Neelakantan H, Watowich S, et al. LC-MS/MS assay for 5-amino-1-methylquinolinium: PK and oral bioavailability in rats. J Pharm Biomed Anal. 2021;204:114255. https://pubmed.ncbi.nlm.nih.gov/34304009/
Pissios P. Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends Endocrinol Metab. 2017;28(5):340-353. https://pubmed.ncbi.nlm.nih.gov/28291578/
Revollo JR, Korner A, Mills KF, et al. Nampt/PBEF/Visfatin regulates insulin secretion as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363-375. https://pubmed.ncbi.nlm.nih.gov/17983582/
PepWise is an informational and educational tracking tool, not medical advice and not a medical device. 5-Amino-1MQ may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.
