Peptide Encyclopedia / Alprostadil
EncyclopediaAlprostadil is synthetic prostaglandin E1 and, unlike most agents in this encyclopedia, an FDA-approved prescription drug. Doctors use it for erectile dysfunction and to keep a newborn's ductus arteriosus open, relaxing smooth muscle to raise blood flow, with a mature evidence record. Educational, not medical advice.
| Category | Sexual Health |
| Regulatory status | FDA-approved prescription drug for erectile dysfunction and for neonatal ductal patency. |
Synthetic prostaglandin E1 that relaxes vascular and cavernosal smooth muscle (via cAMP), increasing arterial inflow to produce erection; also maintains ductus arteriosus patency in neonates by relaxing ductal smooth muscle.
Very short; alprostadil is largely metabolized on first pass through the lungs (minutes). Commonly reported use/dosing: FDA-approved for erectile dysfunction as intracavernosal injection (Caverject, Edex) and intraurethral pellet (Muse), and for maintaining ductus arteriosus patency in neonates by IV infusion. Reported ED use is per-dose self-administration titrated by a clinician.
FDA-approved prescription drug for erectile dysfunction and for neonatal ductal patency. Prescription-only.
Penile pain, prolonged erection/priapism, fibrosis with repeated injection, hypotension; in neonates apnea, flushing, fever. Priapism requires urgent care. Not for use with certain anatomical/clotting conditions.
Mature, well-established for approved indications.
PepWise is an informational and educational tracking tool, not medical advice and not a medical device. Alprostadil may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.
