BPC-157 is a synthetic 15-amino-acid peptide derived from a partial sequence of a protein found in human gastric juice. It is researched, almost entirely in animal and lab models, for tissue, tendon, and gut repair. It is not FDA-approved for any use.

Peptide Encyclopedia / BPC-157

Encyclopedia

BPC-157

Q: Is BPC-157 FDA-approved?

No. BPC-157 has no FDA approval for any indication and is not a lawful dietary supplement. In 2023 the FDA placed it in Category 2 of its 503A interim bulk drug substances list; it was later removed from that category pending further review, which is not authorization to compound. It has been on the WADA Prohibited List since 2022.

BPC-157 is a synthetic 15-amino-acid peptide based on a sequence found in human gastric juice. Almost all of the research on tendon, ligament, and gut repair comes from animal and lab models, human evidence is limited, and it is not FDA-approved. Below you'll find reported dosing, reconstitution, cycling, and the safety and legal lines that matter. Educational only, not medical advice.

Also known as	Body Protection Compound-157, Pentadecapeptide BPC 157, PL 14736 (related)
Class	Synthetic 15-amino-acid peptide (gastric-juice-derived sequence)
Researched for	Tissue, tendon, ligament, and gut repair (mostly animal/lab models)
Typical route	Subcutaneous, often near the area of interest; oral and IM are community practice
Human evidence	Limited. No completed human efficacy trials
Regulatory status	Not FDA-approved. WADA-prohibited since 2022. Research chemical

What BPC-157 is

BPC-157 is a synthetic peptide made of 15 amino acids, based on a partial sequence of a protein found in human gastric juice. In laboratory and animal research it has been studied for wound, tendon, and gut healing. Proposed mechanisms, characterized almost entirely in rodent and in-vitro models, include promoting new blood-vessel growth and influencing growth-factor signaling and connective-tissue repair. Those mechanisms have not been confirmed in controlled human studies.

What people use it for

In community use, BPC-157 is most associated with musculoskeletal recovery: tendon and ligament strains, joint discomfort, and post-injury or post-surgery healing. Some also report gut-related use. It is important to separate reported anecdotal use from proven benefit. The published human evidence base is essentially absent, so any expectation of benefit is not backed by human trials.

Commonly reported dosing

There is no validated or approved human dose for BPC-157. Community protocols commonly report roughly 250 to 500 mcg injected subcutaneously once or twice daily, often near the area of interest, in short courses. Treat these numbers as anecdotal, because they are. A licensed healthcare provider is the right person to weigh whether any use makes sense for you.

A frequent, avoidable mistake here is confusing units on an insulin syringe with the actual dose in micrograms. Units measure the volume you draw, not the amount of peptide, so the same "10 units" can be a very different dose depending on how you reconstituted the vial. Our free peptide dose converter turns mg, mcg, and syringe units into each other so you are not guessing.

Reconstitution

BPC-157 typically ships as a lyophilized (freeze-dried) powder that you reconstitute with bacteriostatic water. Concentration is simply the vial amount in milligrams divided by the water you add. Add more water and each unit on the syringe holds less peptide. Use the reconstitution calculator to get the exact units to draw for your target dose.

Cycling

Community BPC-157 use is commonly organized into short courses of roughly four to six weeks with a break, rather than continuous indefinite use. Because there is no validated protocol, cycle choices are individual. If you do run a cycle, tracking your start date and on/off lengths makes it far easier to see what actually changed. PepWise's cycle tracker counts your days on and left and reminds you before a cycle ends.

Safety and regulatory status

Not FDA-approved. BPC-157 has no FDA approval for any indication and is not a lawful dietary supplement. In September 2023 the FDA placed it in Category 2 of its 503A interim bulk drug substances list (significant safety risks for compounding). It was later removed from Category 2 (effective April 2026) pending Pharmacy Compounding Advisory Committee review; removal is not authorization to compound. WADA-prohibited at all times since 2022 (category S0). Athletes subject to testing should not use it.

Because human safety data is limited, unknown long-term risks cannot be ruled out, and product purity in the research-chemical market varies. This page does not endorse use; it explains what is and is not known so you can have a better-informed conversation with a clinician.

Track BPC-157 in PepWise

If you are using BPC-157 under appropriate guidance, PepWise keeps your doses, reconstitution math, cycle, and how you feel in one private app, then turns it into a provider PDF. See the BPC-157 tracker or start free.

FAQ

What is BPC-157?

A synthetic 15-amino-acid peptide based on a sequence found in gastric juice, researched mostly in animal and lab models for tissue, tendon, and gut repair. Not FDA-approved.

Is BPC-157 FDA-approved?

No. It has no FDA approval and is not a lawful supplement. It has been WADA-prohibited since 2022.

What is a commonly reported BPC-157 dose?

There is no validated human dose. Community protocols commonly report about 250 to 500 mcg subcutaneously once or twice daily in short courses. Anecdotal, not established. Consult a provider.

What is the half-life of BPC-157?

No validated human pharmacokinetic data, including a defined half-life, have been published.

PepWise is an informational and educational tracking tool, not medical advice and not a medical device. BPC-157 is not FDA-approved and may be experimental or restricted where you live. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.