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Peptide Encyclopedia / Dermorphin

Encyclopedia

Dermorphin

Dermorphin is a frog-skin heptapeptide and potent mu-opioid receptor agonist, stronger by weight than morphine. It has no legitimate human protocol, turns up as an illicit doping agent, and holds no FDA approval. As an opioid it risks life-threatening respiratory depression. Educational only, not medical advice.

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CategoryOther
Regulatory statusNot FDA-approved and not an accepted medical product in the US.

Mechanism

A naturally occurring heptapeptide (from Phyllomedusa frog skin) and highly selective, potent mu-opioid receptor agonist, producing strong analgesia and central opioid effects far more potent than morphine by weight.

Half-life

uncertain; limited rigorous human pharmacokinetic data. Commonly reported use/dosing: No legitimate human therapeutic protocol. It has been detected as an illicit doping agent (notably in horse racing). There is no validated or sanctioned dosing.

Regulatory status

Not FDA-approved and not an accepted medical product in the US. As a potent opioid agonist it carries the abuse and diversion concerns of opioids; sale/use is a research-chemical/illicit gray area and prohibited in sport.

Safety

DANGER: as a potent mu-opioid agonist it can cause life-threatening respiratory depression, sedation, dependence, and overdose; risk is magnified by its high potency and unregulated purity. Not for human use.

Evidence

Pharmacology characterized in animal/laboratory research; no legitimate human clinical development.

Sources

PepWise is an informational and educational tracking tool, not medical advice and not a medical device. Dermorphin may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.