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Peptide Encyclopedia / DSIP

Encyclopedia

DSIP

DSIP, or delta sleep-inducing peptide, is a naturally occurring neuropeptide reported to influence sleep and stress responses, though its action in humans stays unclear. Human research remains thin, and it trades as a research chemical, not an FDA-approved drug. Educational only, not medical advice.

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CategoryCognitive
Regulatory statusNot FDA-approved.

Mechanism

Delta sleep-inducing peptide, a naturally occurring neuropeptide reported to influence sleep regulation and stress/neuroendocrine responses; mechanism in humans is not well characterized.

Half-life

Uncertain; reported to be very short (minutes) in circulation.

Regulatory status

Not FDA-approved. The FDA has noted human research on DSIP is still lacking. Was on FDA Category 2; per April 2026 reporting slated for removal from Category 2 (compounding reconsideration only). Research chemical / gray-market.

Safety

Limited human safety data; side effects poorly characterized; long-term safety unknown.

Evidence

Limited human data; mostly older/animal studies and anecdotal use.

Sources

  1. Schneider-Helmert D, Schoenenberger GA. Effects of DSIP in man: multifunctional psychophysiological properties besides induction of natural sleep. Neuropsychobiology. 1983;9(4):197-206. https://pubmed.ncbi.nlm.nih.gov/6895513/
  2. Schneider-Helmert D. Effects of DSIP on narcolepsy. Eur Neurol. 1984;23(5):353-357. https://pubmed.ncbi.nlm.nih.gov/1299794/
  3. Dick P, et al. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. Eur Neurol. 1984;23(5):364-371. https://pubmed.ncbi.nlm.nih.gov/6548969/
  4. Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. Eur Neurol. 1984;23(5):372-385. https://pubmed.ncbi.nlm.nih.gov/6548970/
  5. Khvatova EM, Samartzev VN, Zagoskin PP, et al. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003;24(2):307-311. https://pubmed.ncbi.nlm.nih.gov/12668217/
  6. Prudchenko IA, Mikhaleva II. Delta sleep inducing peptide and its analogues. Bioorg Khim. 2019;45(4):405-416. https://pubmed.ncbi.nlm.nih.gov/31407692/
  7. Koplik EV, Umriukhin PE, Konorova IL, et al. Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection. Neurosci Behav Physiol. 2008;38(9):953-957. https://pubmed.ncbi.nlm.nih.gov/18975112/
  8. Solnyshkova TG, et al. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules. 2021;26(17):5173. https://pubmed.ncbi.nlm.nih.gov/34500610/

PepWise is an informational and educational tracking tool, not medical advice and not a medical device. DSIP may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.