Epitalon is a synthetic tetrapeptide modeled on the pineal peptide epithalamin, reported in mostly Russian and preclinical work to influence telomerase activity and aging-related pathways. It is not FDA-approved, its longevity claims lack rigorous evidence, and long-term human safety is unknown. Below you will find reported dosing, reconstitution, cycling, safety, and legal status. Educational only, not medical advice.
A synthetic tetrapeptide (modeled on the pineal peptide epithalamin) reported (mostly Russian/preclinical) to influence telomerase activity and circadian/aging-related pathways.
Half-life
Uncertain; limited reliable human PK data, likely short.
Regulatory status
Not FDA-approved. Was on FDA Category 2; per April 2026 reporting slated for removal from Category 2 (compounding reconsideration only). Research chemical / gray-market. Anti-aging/longevity claims are not supported by rigorous evidence.
Safety
Limited human safety data; side effects poorly characterized; theoretical concerns about influencing telomerase/cell proliferation. Long-term safety unknown.
Evidence
Limited human data, mostly older Russian studies and animal work plus anecdotal use.
Track Epitalon in PepWise
Log every dose and injection site, get the reconstitution and units math automatically, follow your cycle, and record how you feel, then export a provider report. Epitalon tracker, free to start.
Sources
Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. https://pubmed.ncbi.nlm.nih.gov/12937682/
Anisimov VN, Khavinson VK, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. https://pubmed.ncbi.nlm.nih.gov/14501183/
Korkushko OV, Khavinson VK, Shatilo VB, et al. Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people. Bull Exp Biol Med. 2004;137(4):389-391. https://pubmed.ncbi.nlm.nih.gov/15452610/
Khavinson VK, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuroendocrinol Lett. 2003;24(3-4):233-240. https://pubmed.ncbi.nlm.nih.gov/14523363/
Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. https://pubmed.ncbi.nlm.nih.gov/32019243/
Goncharova ND, Vengerin AA, Shmaliy AV, Khavinson VK. Peptide correction of age-related pineal disturbances in monkeys. Adv Gerontol. 2003;12:121-127. https://pubmed.ncbi.nlm.nih.gov/14743609/
Khavinson VK, Lezhava TA, Monaselidze JR, et al. Peptide Epitalon activates chromatin at the old age. Neuroendocrinol Lett. 2003;24(5):329-333. https://pubmed.ncbi.nlm.nih.gov/14647006/
PepWise is an informational and educational tracking tool, not medical advice and not a medical device. Epitalon may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.
