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Peptide Encyclopedia / HMG

Encyclopedia

HMG

HMG is a purified gonadotropin of FSH and LH activity extracted from postmenopausal urine. It holds FDA approval as a prescription fertility medicine for ovulation induction and for spermatogenesis in hypogonadotropic men, given under specialist monitoring. Below you'll find reported dosing, reconstitution, safety, and legal status. Educational only, not medical advice.

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CategorySexual Health
Half-life30-40 hours
Regulatory statusFDA-approved prescription gonadotropin (e.

Mechanism

Purified preparation of FSH and LH activity (extracted from postmenopausal urine). FSH stimulates follicular/spermatogenic development and LH activity supports steroidogenesis and ovulation.

Half-life

FSH component terminal half-life roughly 30-40 hours. Commonly reported use/dosing: FDA-approved for ovulation induction/controlled ovarian stimulation in assisted reproduction, and for spermatogenesis induction in men with hypogonadotropic hypogonadism. Reported as daily IM/SC injection during stimulation cycles under fertility-specialist supervision.

Regulatory status

FDA-approved prescription gonadotropin (e.g., Menopur; historically Repronex/Pergonal). Prescription-only and used in monitored fertility settings.

Safety

Ovarian hyperstimulation syndrome, multiple gestation, thromboembolic events, abdominal/pelvic discomfort, injection-site reactions; requires monitoring (ultrasound, estradiol).

Evidence

Mature, long-established for approved fertility indications.

Sources

  1. Muir CA, et al. Efficacy of Gonadotropin Treatment for Induction of Spermatogenesis in Men With Pathologic Gonadotropin Deficiency: A Meta-Analysis. Clin Endocrinol. 2024. https://pubmed.ncbi.nlm.nih.gov/39445789/
  2. Lee JA, Ramasamy R. Indications for HCG use in infertility in hypogonadal men. Transl Androl Urol. 2018;7(Suppl 3):S348-S352. https://pmc.ncbi.nlm.nih.gov/articles/PMC6087849/
  3. Ramazanzadeh F, et al. Comparison of rFSH, HCG, and HMG on semen parameters after varicocelectomy: randomized clinical trial. Iran J Reprod Med. 2014;12(8):555-560. https://pmc.ncbi.nlm.nih.gov/articles/PMC4169682/
  4. Coviello AD, et al. Low-dose HCG maintains intratesticular testosterone. J Clin Endocrinol Metab. 2005;90(5):2595-2602. https://pubmed.ncbi.nlm.nih.gov/15713727/

PepWise is an informational and educational tracking tool, not medical advice and not a medical device. HMG may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.