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Peptide Encyclopedia / Kisspeptin-10

Encyclopedia

Kisspeptin-10

Kisspeptin-10 is a ten-amino-acid peptide that binds the KISS1R receptor on hypothalamic neurons, driving GnRH release and downstream LH and FSH secretion. Human research covers fertility and sexual response, though it stays investigational with no FDA approval, selling otherwise as a research chemical. Below you'll find reported dosing, reconstitution, safety, and legal status. Educational only, not medical advice.

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CategorySexual Health
Regulatory statusNot FDA-approved.

Mechanism

A 10-amino-acid fragment of kisspeptin that binds the KISS1R (GPR54) receptor on hypothalamic GnRH neurons, stimulating GnRH release and thereby downstream LH/FSH secretion; it acts upstream of the pituitary in the HPG axis.

Half-life

Short; kisspeptin-10 has a rapid plasma clearance (on the order of a few minutes), in contrast to longer-acting kisspeptin-54.

Regulatory status

Not FDA-approved. Investigational, used in research studies (reproductive endocrinology, fertility, sexual response); sold otherwise as a research chemical.

Safety

Generally well tolerated in controlled research settings; long-term and outpatient safety data are limited. Effects on the reproductive axis warrant caution.

Evidence

Multiple human research studies (fertility, hypothalamic function, sexual response); evidence is investigational, not approved for any indication.

Sources

  1. George JT, et al. Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men. J Clin Endocrinol Metab. 2011;96(8):E1228-E1236. https://pubmed.ncbi.nlm.nih.gov/21632807/
  2. George JT, et al. Kisspeptin-10 stimulates testosterone and LH in men with type 2 diabetes and mild hypogonadism. Eur J Endocrinol. 2013;169(2):229-236. https://pubmed.ncbi.nlm.nih.gov/23153270/
  3. Mills EG, ... Comninos AN, Dhillo WS. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With HSDD: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(2):e2254313. https://pubmed.ncbi.nlm.nih.gov/36735255/
  4. Jayasena CN, et al. Subcutaneous kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. 2009;94(11):4315-4323. https://pubmed.ncbi.nlm.nih.gov/19820030/
  5. Skorupskaite K, et al. The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B. Endocr Rev. 2024;45(1):30-68. https://pubmed.ncbi.nlm.nih.gov/37326967/
  6. Dhillo WS, et al. Kisspeptin-54 stimulates the HPG axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615. https://pubmed.ncbi.nlm.nih.gov/16174713/
  7. Thompson EL, et al. Chronic subcutaneous kisspeptin-54 causes testicular degeneration in adult male rats. Am J Physiol Endocrinol Metab. 2006;291(5):E1074-E1082. https://journals.physiology.org/doi/full/10.1152/ajpendo.00040.2006

PepWise is an informational and educational tracking tool, not medical advice and not a medical device. Kisspeptin-10 may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.