Peptide Encyclopedia / TUDCA
EncyclopediaTUDCA is the taurine-conjugated form of the bile acid UDCA, studied as a chemical chaperone that eases endoplasmic reticulum stress, steadies mitochondria, and protects cells including liver hepatocytes. Human trials in cholestatic liver disease and metabolic conditions exist, though evidence for many supplement claims is still emerging. In the US it sells as a dietary supplement, not an FDA-approved drug. Below you'll find reported dosing, safety, and legal status. Educational only, not medical advice.
| Category | Longevity / Anti-aging |
| Regulatory status | Not FDA-approved as a drug in the US; sold as a dietary supplement. |
A taurine-conjugated, hydrophilic bile acid (the taurine conjugate of UDCA) that acts as a chemical chaperone reducing endoplasmic reticulum (ER) stress and protein misfolding, stabilizes mitochondria, and has anti-apoptotic and cytoprotective effects, including in hepatocytes.
Not well established in humans; bile acids undergo enterohepatic recirculation, complicating a simple half-life estimate (uncertain).
Not FDA-approved as a drug in the US; sold as a dietary supplement. (The parent compound UDCA/ursodiol IS FDA-approved for certain cholestatic liver diseases, but that is a distinct molecule.) TUDCA is approved/used as a pharmaceutical for cholestasis in some other countries (e.g., parts of Europe and Asia), but not by the FDA.
Generally well tolerated in studies; most common reported effects are mild GI symptoms (e.g., diarrhea). Long-term human safety data at supplement doses are limited; quality varies across unregulated supplement products.
Some human trials (cholestatic liver disease, metabolic/ER-stress conditions) plus substantial preclinical data; evidence for many marketed supplement claims is still emerging.
PepWise is an informational and educational tracking tool, not medical advice and not a medical device. TUDCA may be experimental, restricted, or prescription-only; many research peptides are not FDA-approved. Consult a licensed healthcare provider before starting, changing, or stopping any protocol. Operated by STC Consulting, Inc.
